To explore whether GAS5 inhibits NSCLC/DDP cell metastasis by inducing EMT progression, we carried out immunofluorescence and Western blotting to evaluate the mesenchymal marker expression, Vimentin and the epithelial marker expression, E-cadherin in H1299/DDP cells after GAS5 upregulation. This evidence concerns the gene GAS5 and non-small cell lung carcinoma.