LHPP and non-small cell lung carcinoma: Dual luciferase reporter results showed that luciferase activity was significantly decreased in A549/DDP and H1299/DDP cells transfected with pmiR-Glo-LHPP-wt, while there was not change in NSCLC/DDP cells transfected with pmiR-Glo-LHPP-mut (Figure 3B).