Supplementation of genetically engineered Lactobacillus fermentum expressing recombinant SOD, hyperthermostable SOD from Thermus thermophilus HB27, or SOD mimics having enhanced stability and activity and ameliorated colitis severity in both mouse and human models.57, 58, 59, 60 In addition, treatment with genetically engineered Lactobacillus casei BL23 or Streptococcus thermophilus CRL807 expressing recombinant CAT or SOD restored endogenous antioxidant pools and reduced disease severity in colitis models.61 This evidence concerns the gene SOD1 and colitis.