Instead, we examined the sufficiency of chronic systemic IL-4 to induce reprogramming of BMDM by placing male ApoE-/- mice on HFD for 4–5 weeks and then administering IL-4 complexes (IL-4c, [43]) to ApoE-/- mice on HFD for ~4.5 weeks to mimic the time period of egg antigen exposure in our infection model (egg laying begins at 6 weeks post S. mansoni infection) and then harvested bone marrow. This evidence concerns the gene APOE and infection.