We detected a positive Wald ratio effect between the expression of three genes (CR1, CCDC6, TSPAN14), and a negative Wald ratio effect between the expression of 6 genes (AC012146. 1, PRSS36, ZNF646, KAT8, ACE, CCNT2-AS1) and the risk for Alzheimer’s disease. The gene discussed is ACE; the disease is early-onset autosomal dominant Alzheimer disease.