MAPT and early-onset autosomal dominant Alzheimer disease: Neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), frontotemporal lobar degeneration with tau (FTLD-tau) and amyotrophic lateral sclerosis (ALS) are proteinopathies, characterized by the misfolding and aggregation of signature proteins [58].