When grade, pT stage, lymph node metastasis stage, PD-L1, CD39, CD73, A2AR and histology (ccRCC vs. non-ccRCC) were correlated in Cox univariate analysis, higher histological grade, higher pT stage, positive lymph node metastasis, and higher CD73 and A2AR were associated with shorter overall survival. This evidence concerns the gene ENTPD1 and metastatic malignant neoplasm in the lymph nodes.