When grade, pT stage, lymph node metastasis stage, PD-L1, CD39, CD73, A2AR and histology (ccRCC vs. non-ccRCC) were correlated in Cox univariate analysis, higher histological grade, higher pT stage, positive lymph node metastasis, and higher CD73 and A2AR were associated with shorter overall survival. Here, ENTPD1 is linked to nonpapillary renal cell carcinoma.