CD274 and neoplasm: The B7 family of immune-regulatory ligands, such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) and programmed cell death 1 (PD-1)/PD-ligand 1 (PD-L1), are key players in immune checkpoints that positively or negatively regulate various immune responses, and tumor cells use this regulatory mechanism to evade a tumor-directed T-cell response by upregulating CTLA4 or PD-1/PD-L1 [3, 4].