Although the different roles of the expression of PD-L1, CD39, CD73, and A2AR in tumor and immune cells were unclear, our findings suggested that the influence of the A2AR pathway and the PD-1/PD-L1 axis on the interaction between the immune system and tumor cells in the tumor microenvironment might be linked with cancer progression in RCC. Here, ADORA2A is linked to renal cell carcinoma.