Yet, a limited fraction of NSCLC patients respond to immune checkpoint blockade consisting of anti-PD-1/PD-L1 (Programmed death 1/Programmed death-ligand 1) and CTLA-4 (Cytotoxic T Lymphocyte-associated 4); perhaps warranting the need for other combinatorial immunotherapeutic regimens to potentiate anti-tumor effects of ICI. The gene discussed is CD274; the disease is neoplasm.