Compared with low levels, high EN-RAGE levels were associated with higher dementia prevalence (model 2 adjusted odds ratio [OR], 3.68 [95% CI, 1.50-8.03]; P = .003), and high S-RAGE levels were associated with lower dementia prevalence (model 2 adjusted OR, 0.37 [95% CI, 0.17-0.78]; P = .01) (Table 2). The gene discussed is AGER; the disease is dementia.