AGER and dementia: We found no significant difference in risk of incident dementia among participants with a high EN-RAGE level compared with those with a low level (model 2 adjusted hazard ratio [HR], 0.65 [95% CI, 0.42-1.01]; P = .05), nor for participants with high S-RAGE levels compared with those with low levels (model 2 adjusted HR, 1.22 [95% CI, 0.82-1.81]; P = .33) (Table 2).