AGER and dementia: Diabetes is an established risk factor for dementia, but the exact mechanism remains unclear.1 Accelerated formation of advanced glycation end products (AGEs) has been proposed as a link.2 AGEs are a group of molecules generated nonenzymatically by attaching sugars to proteins, lipids, or nucleic acids and lead to modification and cross-linking of proteins.3 Furthermore, activation of the AGE receptor (RAGE) by AGEs or by other RAGE ligands, including amyloid-β, results in an inflammatory response and subsequently to upregulation of the receptor.4