AGEs can be measured in the skin using skin autofluorescence, a proxy associated with accumulation of AGEs in long-lived tissues, including the brain.17,18 Circulating molecules that are involved in the AGE-RAGE system include extracellular newly identified RAGE-binding protein (EN-RAGE), a RAGE ligand that has been associated with several chronic inflammatory diseases and coronary heart disease,19,20 and the soluble form of RAGE (S-RAGE), which acts as a decoy for RAGE ligands and may have an anti-inflammatory effect.21 Here, AGER is linked to coronary artery disorder.