Thus, a sample for basal LH measurement could be obtained by the primary care physician for initial management: a LH level higher than 0.1 IU/L, would mean a reasonable suspicion of puberty status that should be confirmed by GnRH stimulation; if basal LH level was higher than 1.0 IU/L, the girl should be referred for additional assessment concerning the etiology of precocious puberty and to determine adequate treatment by the pediatric endocrinologist. This evidence concerns the gene PLOD1 and puberty.