Thus, a sample for basal LH measurement could be obtained by the primary care physician for initial management: a LH level higher than 0.1 IU/L, would mean a reasonable suspicion of puberty status that should be confirmed by GnRH stimulation; if basal LH level was higher than 1.0 IU/L, the girl should be referred for additional assessment concerning the etiology of precocious puberty and to determine adequate treatment by the pediatric endocrinologist. Here, GNRH1 is linked to puberty.