Interestingly, the use of FGF23 as biomarker in combination with the N-terminal pro-brain natriuretic peptide (NT-pro-BNP), as a marker of cardiac stretch and myocyte injury, high sensitivity CRP (hs-CRP), as a marker for chronic inflammation and cystatin C, as a marker for kidney function, significantly improved the prediction of death in a cohort of patients with advanced CKD [177]. The gene discussed is FGF23; the disease is chronic kidney disease.