Interestingly, overexpression of dentin matrix protein (Dmp1) in B6-Col4a3-knockout mice lowers plasma c- and iFGF23 levels and prevents LVH determined by cardiomyocyte area and perimeter, left ventricular mass and left ventricular posterior wall thickness despite no change in hypertension, blood pressure and kidney function and in the presence of persistent hyperphosphatemia [214]. The gene discussed is COL4A3; the disease is hypertensive disorder.