Similar in osteoblast/osteocyte-specific Fgf23-knockout mice (Fgf23fl/fl Dmp-cre), induction of CKD by adenine diet resulted in higher serum Pi and blood urea nitrogen as well as increased aortic calcification and more pronounced cardiac hypertrophy compared with wild-type mice with adenine-induced CKD [202]. The gene discussed is FGF23; the disease is chronic kidney disease.