In certain developing countries, the limited availability and cost of these and other modern medicines, such as metformin, sulphonylureas, thiazolidenediones, SGLT2 inhibitors and insulin formulations, have resulted in increasing attention being paid to traditional plant medicines with reputed anti-diabetic activity for treatment of T2DM [3,8,10,16–18]. The gene discussed is INS; the disease is type 2 diabetes mellitus.