SPHK1 and pulmonary arterial hypertension: MiR-1-3p regulates cell proliferation, apoptosis, and invasion by targeting chemokine C–C motif ligand 2 (CCL2), protein regulator of cytokinesis 1 (PRC1) and c-mesenchymal epithelial transition factor (c-MET), also takes part in the reconstruction of pulmonary blood vessels during pulmonary hypertension through sphingosine kinase 1 (SPHK1) [34].