Abbreviations: BPH: Benign Prostate hyperplasia; OS: Oxidative Stress; NF: Neferine; SFN: Sulforaphane; ROS: Reactive Oxygen species; MDA: Malondialdehyde.; SOD: Superoxide dismutase; GST: Glutathione-s-transferase; ARE: Antioxidant response element; Nrf2: Nuclear factor erythroid 2-related factor-2; HO-1: Heme oxygenase-1; NQO1: NAD(P)H Quinone Dehydrogenase-1; Keap1: Kelch-like ECH-associated protein-1; Bax: Bcl-2 associated X protein; Bcl2: B cell lymphoma-2; Cyt-C: Cytochrome-C. The gene discussed is HPGDS; the disease is benign prostatic hyperplasia.