In order to demonstrate the applicability of iNs as a relevant disease model in neurodegenerative disorders, we generated and characterised iNs from fibroblasts from transgenic porcine models carrying AD-causing mutations in APP (Swedish mutation; APPsw) and/or PSEN1 (PSEN1M146I) (skin biopsies from 12 to 20 weeks old pigs) [31, 32]. The gene discussed is PSEN1; the disease is Alzheimer disease.