MFN2 and Alzheimer disease: In an analysis of AD-CMT2A cases with variants residing within the dynamin-GTPase domain (amino acid positions 93–342) versus AD-CMT2A cases with variants outside the domain (Table 2), there were no significant differences in the age of onset of symptoms, baseline mean CMTESv2, CMTESv2-R, CMTNSv2, CMTNSv2-R and CMTPedS scores and both groups had similar disease duration periods.