None of the category groups of age of onset of symptoms (child versus adult onset AD-CMT2A), variant topology (GTPase domain variants versus non-GTPase domain variants) or the biological effect of certain variants on mitochondrial fusion dynamics (hypofusion versus hyperfusion variants) had statistically significant enrichment with cases of CMT2A and concurrent optic atrophy. Here, MFN2 is linked to Charcot-Marie-Tooth disease type 2A1.