IL10 and infection: Although early work suggested that IL-10 is not involved in Th1 differentiation due to anti-IL-10 treatment of C3H/HeN and BALB/c mice [85], later studies contradicted this conclusion as L. major infected IL-10-/- BALB/c mice footpad displayed 1000-fold lesser parasite at five weeks post-infection compared to WT BALB/c [86].