IL-1β levels are elevated in ADbrain as IL-1β was produced in response to Aβ exposure in cellculture (Meda et al., 1999) and was shown to contribute tocognitive deficits, tau phosphorylation and Aβ pathology in aged3× Tg-AD mice (Kitazawa et al.,2011). This evidence concerns the gene IL1B and Alzheimer disease.