To confirm whether IL-17 and IL-17R protein overexpression was correlated with LC pathologic grading, the IHC was performed on 60 LC tissue samples which included paracancerous tissues of the normal control group (10 cases), well-differentiated group (12 cases), moderately differentiated group (22 cases), and poorly differentiated group (16 cases). This evidence concerns the gene IL17A and laryngotracheoesophageal cleft.