In addition, IL-17 may be significantly correlated with the differentiation and angiogenesis in the development of LC as the expression of CXCL9, CXCL10, and IL-17 mRNAs in the skin of FAS- and FASL-deficient mice was decreased [27, 36, 37]. This evidence concerns the gene CXCL9 and laryngotracheoesophageal cleft.