HIF1A and cancer: The top 10 KEGG pathways were as follows: glycolysis/gluconeogenesis, the HIF-1 signaling pathway, central carbon metabolism in cancer, fructose and mannose metabolism, the PI3K-Akt signaling pathway, the Pentose phosphate pathway, proteoglycans in cancer, starch and sucrose metabolism, protein processing in the endoplasmic reticulum, and neomycin, kanamycin, and gentamicin biosynthesis (Figure 5).