AKT1 and cancer: Furthermore, the KEGG circus diagram of the top 15 Hub genes showed that they were mainly involved in the HIF-1 signaling pathway, the PI3K-Akt signaling pathway, glycolysis/gluconeogenesis, central carbon metabolism in cancer, proteoglycans in cancer, protein processing in the endoplasmic reticulum, fructose and mannose metabolism, and the pentose phosphate pathway(Figure 6(e)).