GZMB and colonic neoplasm: It is reported that CD3+ T lymphocytes, CD8+ T lymphocytes, and the effector molecule granzyme B infiltration are correlated with OS of colon cancer but not rectal cancer [45], while lymphocytic infiltration is associated with relapse and distant metastasis of rectal cancer but not colon cancer according to the study of Nagtegaal et al. [46].