Paratocarpin E, a prenylated chalcone, can induce apoptosis via the intrinsic pathway and activate autophagy by increasing autophagic vacuoles and upregulating autophagic proteins Beclin-1 and LC3-I/II via the p38/ERK/JNK pathway in human breast cancer MCF-7 cells [60]. The gene discussed is MAPK8; the disease is breast cancer.