Although few therapies target AhR to improve intestinal barrier function in patients with CKD, the potential exists to uncover many novel avenues to delay CKD progress; for example, baicalein, a flavonoid from Scutellaria baicalensis used in Chinese herbal medicine, induces regulatory T-cell differentiation through AhR and enhances intestinal barrier function through its regulation of tight junctions in a mouse model of food allergies (Bae et al., 2016). The gene discussed is AHR; the disease is chronic kidney disease.