Compared with healthy controls, CKD patients and 5/6 of nephrectomy mice exhibited increased serum AhR-activating potential, which was strongly correlated with IS concentration and estimated glomerular filtration rate, and which upregulated expression of the AhR target genes AhRR and Cyp1A1 (Dou et al., 2018). The gene discussed is AHR; the disease is chronic kidney disease.