IL1R1 and retinopathy of prematurity: The battery of in vitro examinations used in this study has further validated the importance of such pathways for in vivo activity; however, the capacity of N-oxyphthalimide 2f to reduce vaso-obliteration and microglial activation in the OIR model without effects on kinase phosphorylation and gene expression demonstrates the probability that other IL-1R mediated pathways may be valid targets for the indication of ROP.