REN and Hyponatremia: 3β-HSD2 enzyme converts Δ5-3β-hydroxysteroids into corresponding Δ4-3-keto isomers, Preg to Prog, 17α-hydroxypregnenolone (17OHPreg) to 17α-hydroxyprogesterone (17OHP), dehydroepiandrosterone (DHEA) to Δ4-androstenedione (Δ4A), and androstenediol to T. In SW HSD3B2-D, glucocorticoid and mineralocorticoid are impaired causing hyponatremia, hyperkalemia, and elevated renin concentrations in both sexes.