Of the top 40 signaling pathways with −log10 (p-value) >1.9, nine showed enrichment exclusively in PD-L1+ clear cell ovarian cancer as compared to metastatic HGS and primary HGS ovarian cancer including circadian rhythm, several metabolic pathways such as pentose phosphate, WNT/Ca+ signaling and GABA receptor signaling. Here, CD274 is linked to ovarian cancer.