There were numerous NADH dehydrogenase (uniquinone) 1 alpha (NDUFA) genes that were downregulated in our cohort relative to HGS cancers, which is in contrast to renal clear cell carcinoma in which NDUFA4L2 expression is high, serving as a novel molecular target for treatment (35). Here, COXFA4L2 is linked to clear cell renal carcinoma.