Our population showed downregulated genes in the ovarian CCC cohort as compared to the HGS ovarian cancers in several canonical pathways including the PI3K/AKT pathway, as well as in mitochondrial dysfunction, oxidative phosphorylation, protein ubiquitination, NER pathways, integrin signaling, BMP, and ATM signaling. The gene discussed is PIK3CA; the disease is ovarian cancer.