CD274 and cancer: Core canonical pathway analysis for the most significantly differentially expressed 2,000 genes in each dataset was used to identify 56 pathways that were enriched for differential gene transcription in PD-L1+ ovarian CCC as compared to PD-L1− ovarian CCC, 164 such pathways for metastatic HGS cancer compared to primary HGS tumors, and 201 such pathways for primary HGSOC compared to normal tubal tissue.