Lactate, a byproduct of aerobic glycolysis, is shuttled to the extracellular space and was shown to support stemness by upregulation of the expression of genes related to stem cell properties, such as transcription factor SP1, sterol regulatory element-binding protein 1 (SREBP1) which is a transcriptional activator required for regulation of lipid homeostasis, etc., to increase aggressiveness and invasive properties of cancer cells as well as to promote immunosuppression (43–48). The gene discussed is SREBF1; the disease is cancer.