OCLN and serum lipopolysaccharide activity: Prior studies indicate that high-fat feeding can reduce the expression of tight junction proteins occludin and zona-occludens (ZO)-1 and also increase plasma endotoxemia in C57bl6/J mice [31], whereas protein expression of occludin was not significantly different between groups and low-dose OMC supplementation was associated with higher expression of occludin in the proximal small intestine of both the Chow and HFD-fed rats.