The results from the current study show that (1) a 10-week HFD induced gut dysbiosis, as well as hepatic steatosis and accumulation of advanced glycation end products (CML) in young male Sprague-Dawley rats; (2) although OMC did not prevent hepatic steatosis, it was effective at preventing HFD-induced changes to the gut microbiome and hepatic CML levels; and (3) OMC may help prevent gut leakiness as it promoted the expression of occludin in the small intestine. This evidence concerns the gene OCLN and Hepatic steatosis.