MMP3 and osteoarthritis, knee: Schell et al. [83] found that obese adults with knee osteoarthritis drank a reconstituted freeze-dried strawberry beverage (50 grams daily) for twelve weeks, and it was more effective at reducing serum biomarkers of inflammation and cartilage degradation, IL-6, IL-1β, and matrix metalloproteinase-3 (MMP-3), compared with the control beverage.