The interactions between these TFs were reported in the literature, such as Creb1, and were found to bind to endogenous Egr1 promoters [27]; Smad3 and Egr1 interacted via the Smad3 MH2 domain and the EGR1 DNA-binding domain [28]; Creb1 can also bind to the TGFB2 gene promoter in cooperation with Smad3 in glioblastoma [29]; FoxO1 can bind to Smad3 [30]. This evidence concerns the gene FOXO1 and glioblastoma.