A dietary intake of ER in mice decreases lipogenesis-related qualities, and an improvement in insulin resistance was reported by suppressing hepatic gluconeogenesis, enhanced glucose metabolism, and modulated the synthesis and discharge of incretin hormones, namely, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) [42]. The gene discussed is GCG; the disease is Insulin resistance.