Unfortunately, the number of deaths was too low to perform a valid statistical analysis; however, we observed that among the patients who died from cardiac causes, all had dcSSc—the two who died from heart failure had very high NT-proBNP levels, slightly high hs-cTnT levels, and severely impaired left ventricular systolic function (left ventricular ejection fraction <35%), and the one who died from cardiac arrhythmia had high normal NT-proBNP level but remarkably high hs-cTnT level though normal left ventricular ejection fraction. This evidence concerns the gene NPPB and chronic obstructive pulmonary disease.