In cancer, low SOCS2 gene expression was associated with breast cancer, lung cancer, hepatocellular carcinoma, and ovarian cancer (Wikman et al., 2002; Sutherland et al., 2004; Farabegoli et al., 2005; Haffner et al., 2007; Qiu et al., 2013; Zhu et al., 2013). This evidence concerns the gene SOCS2 and cancer.