In our study, This is consistent with our analysis that IGFBP-3 is highly expressed in HCC, and high IGFBP-3 expression is associated with poor prognosis of HCC.IGFBP-3 was highly expressed in HCC, and the high expression of IGFBP-3 is associated with poor prognosis of HCC. Here, IGFBP3 is linked to hepatocellular carcinoma.