In breast cancer (Yu et al., 1998; Sheen-Chen et al., 2009), pancreatic cancer, (Xue et al., 2008), and clear cell renal cell carcinoma (Takahashi et al., 2005), the high expression of IGFBP-3 is associated with poor prognosis. The gene discussed is IGFBP3; the disease is familial pancreatic carcinoma.