Besides, the top 10 HCC related hub genes were screened according to MCC scores from the CytoHubba plugin in Cytoscape, including FOS, EGR1, EPHA2, DUSP1, IGFBP3, SOCS2, ID1, DUSP6, MT1G, and MT1H. This evidence concerns the gene DUSP1 and hepatocellular carcinoma.