Lian et al. (2020) found that ubiquitin specific peptidase 5 (USP5) enhances STAT3 signaling and promotes migration and invasion in pancreatic cancer. Chen et al. (2020) found that E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPα. Yang et al. (2019) found that USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1. Here, STAT3 is linked to familial pancreatic carcinoma.