In this study, multiple studies on the definition of clopidogrel resistance were integrated, and domestic and foreign studies on the correlation between Cyp2C19*2 gene polymorphism and clopidogrel resistance in coronary heart disease were collected to comprehensively analyze the relationship between them, so as to provide more in-depth evidence-based medicine for clinical practice. Here, CYP2C19 is linked to coronary artery disorder.