Chemokine CCL2 and CCL5 in prostate and ovarian cancer promoted MMP-2 and MMP-9 secretion by ERK, Rac signaling (55); in chondrosarcoma through Ras/Raf-1/MEK/ERK/NF-κB and in breast and liver cancer via PI3K/Akt and GSK-3β pathways (52, 53). The gene discussed is AKT1; the disease is liver cancer.