CCL20 and neoplasm: Furthermore, co-culture of monocyte-derived macrophages which is a major source of CCL20 with hepatoma cells induces EMT and accelerates tumor metastases in a CCL20-dependent manner (20, 61, 64) by activation of P38 MAPK (96), CrkL-ERK1/2 (97) and JAK2/STAT3 pathways (65).