Similarly, CCL20/CCR6 binding leads to MMP2 upregulation via JAK2/STAT3 and CrkL-Erk1/2 pathways, and MMP9 upregulation through the activation of PKC-α, src, Akt, and NF-κB pathways in breast and gastric cancer (65, 97). This evidence concerns the gene MMP2 and gastric cancer.