The X-C Motif Chemokine Receptor 1 gene encodes a chemokine receptor belonging to the G protein-coupled receptor superfamily. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor. XCR-associated diseases include Leber plus disease. This evidence concerns the gene CXCR6 and Leber plus disease.