The FYVE And Coiled-Coil Domain Autophagy Adaptor 1 gene encodes a protein with a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. FYCO1-associated diseases include autosomal recessive congenital cataract-2. The gene discussed is FYCO1; the disease is early-onset nuclear cataract.