LZTFL1 and neoplasm: The Leucine Zipper Transcription Factor Like 1 gene encodes an ubiquitously expressed protein localized in the cytoplasm. LZTFL1 regulates protein trafficking to the ciliary membrane via interactions with Bardet-Biedl Syndrome (BBS) proteins. It may also function as a tumor suppressor by interacting with E-cadherin and the actin cytoskeleton to regulate the transition of epithelial cells to mesenchymal cells. LZTFL-associated diseases include Bardet-Biedl Syndrome 17 and Bardet-Biedl Syndrome 1.