The FYVE And Coiled-Coil Domain Autophagy Adaptor 1 gene encodes a protein with a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. FYCO1-associated diseases include autosomal recessive congenital cataract-2. This evidence concerns the gene MAP1LC3A and early-onset non-syndromic cataract.