Paxillin (PXN) and Cytoskeleton organizer collapsin response mediator protein 2 (CRMP2) which are involved in cell migration pathway are increased in CD4+ T-cells of HAM/TSP patients and HTLV-1 infections, respectively (Varrin-Doyer et al., 2012; Pinto et al., 2013). Here, CD4 is linked to tropical spastic paraparesis.