FOXP3 and tropical spastic paraparesis: In spite of all the evidence, conflict exists whether loss of Foxp3 is associated with reprogramming of Tregs or Foxp3 loss in conventional T-cells (Miyao et al., 2012; Yamamoto-Taguchi et al., 2013) or whether Foxp3 expression is increased or decreased in HAM/TSP (Yamano et al., 2005; Oh et al., 2006; Hayashi et al., 2008; Toulza et al., 2008; Araya et al., 2011; Pinto et al., 2013; Bangham et al., 2015).