FGFR4 and hepatocellular carcinoma: FGF19 is however, also a strong inducer of liver carcinomas in mice (108) and it is of high importance to mitigate the mitogenic, FGFR4-mediated effect of FGF19 to allow human therapy, even though species difference may indicate that FGF19 is less mitogenic in human cellular systems (109, 110).