Finally, the molecules involved in hemostasis, as procoagulant or anticoagulant, should be deeply investigated for their potential relationship with Midkine, such as thrombin and thrombomodulin that are described to interplay each other to determine different effects on hemostasis (Rezaie, 2010) and have associated with NETs occurrence (Toh et al., 2016): Midkine could alter the balance between procoagulant and anticoagulant and could foster thromboinflammatory response and intravascular thrombosis during COVID-19 occurrence. Here, MDK is linked to COVID-19.