Interestingly, lysine-specific demethylase 3A (KDM3A) enhanced transforming growth factor β-induced factor 1 (TGIF1), inhibited fibronectin, alpha skeletal muscle actin (α-SMA) as well as the phosphorylation of Smad2/3 to curtail renal fibrosis (Ding et al., 2020). The gene discussed is ACTA1; the disease is renal fibrosis.