Sarcopenic obesity, lipid profiles (increases in total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides), reduced insulin sensitivity and diabetes, increased inflammation, atherogenic plaque formation, and plaque destabilization (Scragg et al., 2004; Faris and Smith, 2010; Tzortzis et al., 2017). The gene discussed is INS; the disease is diabetes mellitus.