FNDC5 and brain ischemia: Consistently, a recent study has indicated that brain edema and neurological function are alleviated by irisin during cerebral ischemia-reperfusion in mice and inflammation factors such as IL-1β and TNF-α are decreased and that apoptosis is reduced in the hippocampal neurons as a result of irisin treatment via activation of the Notch signaling pathway (Jin et al., 2019).