Alzheimer's disease (AD) is characterized by an accumulation of protein aggregates composed of amyloid-β peptide (Aβ) and tau in CNS tissues impairing cognitive function and the pathogenesis is believed to be associated with increased permeability of the gut and blood-brain barrierinduced by microbiota dysbiosis (Jiang C. et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.