On the contrary, another experimental study on mice and worms with an intestinal deletion of SIRT1 increased Paneth and goblet cell number and upregulated anti-bacterial peptides such as lysozyme and cryptidines resulting in a rearrangement of the gut microbiota, thus protecting them from colitis-induced colorectal cancer (Lo Sasso et al., 2014). This evidence concerns the gene SIRT1 and colitis.