SIRT1 deficiency in the intestinal epithelium as studied with SIRT1 intestinal knock out mice, resulted in altered gut microbial composition, increased intestinal inflammation, and susceptibility to colitis implicating SIRT1 importance in maintaining intestinal tissue homeostasis through modulation of the gut microbiota (Wellman et al., 2017). This evidence concerns the gene SIRT1 and colitis.