Increased signs of DNA damage, cell death, and hyperphosphorylated Tau, all features of neurodegenerative diseases, were observed in SIRT6-deficient mice brain (Kaluski et al., 2017) indicating the importance of SIRT6 regulation of DNA repair and maintenance of genomic stability to keep the brain healthy (Giblin et al., 2014; Kugel and Mostoslavsky, 2014). The gene discussed is SIRT6; the disease is neurodegenerative disease.