MAPT and Alzheimer disease: Overexpression of SIRT1 and the addition of resveratrol has shown to provide neuroprotective effects in various animal models of AD by reducing amyloid plaque formation and neurofibrillary tau pathology (Chen et al., 2005; Qin et al., 2006; Kim et al., 2007; Green et al., 2008; Karuppagounder et al., 2009; Min et al., 2010; Vingtdeux et al., 2010).