SOX2 and neoplasm: Analysis of HCC1806 xenografts also showed a similar trend in MCSC markers (Aldh1 and Sox2) of tumor cell (human) origin in the NIC plus HFD group compared to the control saline group: Aldh1 (hAldh1: 3.1 ± 0.6-fold, p ≤ 0.01; mAldh1: 2.5 ± 0.4-fold, p ≤ 0.05) and Sox2 (hSox2: 3.8 ± 0.6-fold, p ≤ 0.01; mSox2: 2.6 ± 0.5-fold, p ≤ 0.05) (Figure 1(f)).