BCL2 and neoplasm: The predominant role of BCL-2 family is to regulate cell survival by modulating the integrity and the release of apoptogenic factors.28 Not surprisingly, BCL-2 overexpression has been linked to tumorigenesis initiation and the development of resistance to chemotherapies.29 Due to their regulatory roles in apoptosis, members of the BCL-2 family are considered as promising targets for cancer therapy.28,29 VCX is a potent and selective BCL-2 inhibitor with anti-tumor properties that usually correlates with its inhibitory effect on BCL-2.