Our findings are in an agreement with previous observations, which showed that VCX induces apoptosis10 in breast cancer cells through BAX-dependent mechanism.33,34 Increased cell apoptosis by VCX in the current study was associated with induction of cell cycle arrest in G0/G1, leading to an increase in the percentage of cells in the G0/G1 phase with a decrease in the S phase cell population. Here, BAX is linked to breast cancer.