MKI67 and ductal breast carcinoma in situ: These results are in contrast to prior studies, where Ki67 and COX2 expression were associated with recurrence.18 Importantly, mRNAs of the proliferation related genes play an important role in Oncotype Dx DCIS score.19 One possible explanation of these differences is that we used an automated quantitation method of signal intensity for all cells included in the analysis and our final unit of measurement for each cell was median nuclear intensity.