Most interestingly, the gene of prostate transmembrane protein androgen induced 1 (PMEPA1), a known suppressor of metastasis and negative regulator of transforming growth factor-β (TGF-β) signaling in PCa, was down-regulated after CHD1-KD in both models (Fig. 2a), which could be validated by qPCR (Fig. 2b). The gene discussed is CHD1; the disease is posterior cortical atrophy.