Our research team had previously proved that overexpression of heme oxygenase-1 (one of Nrf2 target genes) promoted proliferation and increased resistance to Ara-C-induced apoptosis of AML cells in vitro and the leukemia’s progression of AML in vivo by activating the JNK/c-Jun signaling pathway42. The gene discussed is MAPK8; the disease is acute myeloid leukemia.