Indeed, silencing of BTF3 via shRNA resulted in significantly attenuated growth of PC-3 and DU145 prostate cancer cells cultured in both 2D and 3D conditions, enhanced apoptotic cell death (Fig. 1c and Supplementary Fig. S1a–e), as well as mitigated migration and invasion potential (Supplementary Fig. S1f–g). The gene discussed is BTF3; the disease is Familial prostate cancer.