KDM6B and posterior cortical atrophy: To further test the effects of KDM6B KD on PCa growth in vivo, nude mice were subcutaneously implanted with PC3 and C42B cells, and the combination of in vivo-jetPEI delivery reagent and the KDM6B siRNA were applied to knock down KDM6B expression in xenograft (Supplemental Fig. 2C, D).