At the mRNA level, GEO:GSE6919, GEO:GSE35988, and GEO:GSE6752 datasets indicated that KDM6B expression was upregulated in PCa compared to the expression in the normal control, and the expression was even higher in metastatic PCa (Fig. 1A and Supplemental Fig. 1B). Here, KDM6B is linked to posterior cortical atrophy.